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饮食养生:胆固醇如何代谢

作为合成上述生物分子的结构单位前体。

As a precursor of structural units for the synthesis of the above biomolecules.

胆固醇大部分可转变为胆汁酸。

Most cholesterol can be converted into bile acids.

2、胆固醇合成部位和合成原料分别是什么几乎全身各组织均可合成胆固醇,肝是合成胆固醇的主要场所。

2. What are the synthetic parts and raw materials of cholesterol synthesis? Almost all tissues of the body can synthesize cholesterol. Liver is the main place to synthesize cholesterol.

胆固醇合成酶系存在于胞液及光面内质网上。

Cholesterol synthase is present in cytoplasm and smooth endoplasmic reticulum.

合成胆固醇的原料为乙酰辅酶a和nadph,此外还需atp提供能量,乙酰辅酶a是葡萄糖、氨基酸和脂肪酸在线粒体内的代谢分解产物。

The raw materials for cholesterol synthesis are acetyl coenzyme A and NADPH. In addition, ATP is needed to provide energy. Acetyl CoA is the metabolite of glucose, amino acids and fatty acids in mitochondria.

合成反应所需nadph主要来自磷酸戊糖途径。

The NADPH required in the synthesis mainly came from pentose phosphate pathway.

2、胆固醇 胆固醇可反馈抑制肝脏合成胆固醇,它主要抑制hmg-coa还原酶的合成。

2. Cholesterol cholesterol can feedback inhibit the synthesis of cholesterol in liver, which mainly inhibits the synthesis of HMG CoA reductase.

胰高血糖素和皮质醇能抑制并降低hmg-coa还原酶的活性,因而减少胆固醇的合成。

Glucagon and cortisol can inhibit and decrease the activity of HMG CoA reductase, thus reducing the synthesis of cholesterol.

有人曾发现给动物喂食缺乏胆固醇的食物,结果这些动物的红细胞脆性增加,容易引起细胞的破裂。

It has been found that feeding animals with cholesterol deficient food results in increased fragility of red blood cells and easy to cause cell rupture.

3、激素是协调多细胞机体中不同细胞代谢作用的化学信使,参与机体内各种物质的代谢,包括糖、蛋白质、脂肪、水、电解质和矿物质等的代谢,对维持人体正常的生理功能十分重要。

3. Hormones are chemical messengers that coordinate the metabolism of different cells in a multicellular organism. They participate in the metabolism of various substances in the body, including sugar, protein, fat, water, electrolytes and minerals, which are very important for maintaining normal physiological functions of the human body.

饮食养生:胆固醇如何代谢

作为合成上述生物分子的结构单位前体。As a precursor of structural units for the synthesis of the above biomolecules.胆固醇大部分可转变为胆汁酸。Most cholesterol

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